Erwin spent few days on Ellis Island that was the busiest immigration station of America. The inspection team noticed the title of doctor with his name albeit he immigrated here on a student visa.
That thing was suspicious in the eyes of immigration office and he spent few days on Ellis Island immigration station. After that he rescued by Johnson who was a Chemistry professor at Yale University.
During this time, he discovered two branched-chain fatty acids. Erwin also studied about the Tuberculosis bacterium in this same University. He learned the new research methods in Bacterial Chemistry and despite his experience in empirical scientific work, Erwin was nominated for the job in America but he rejected this offer and returned to Europe due to culture shock and the great depression. Chargaff stayed in United States until and subsequently he moved to Europe.
From to , he joined as an assistant of Chemistry in the public health department of bacteriology in the Berlin University. Erwin Chargaff considered these two and a half years in Berlin University were the best years of his life. In , Hitler came to power in Germany.
Erwin Chargaff was however a Jewish and the new Nazi policies of Hitler were against the Jews community. To save his life, Erwin leaved Berlin immediately and relocated to France where he joined the Pasteur Institute in Paris.
He moved to Paris and started work on polysaccharides and bacterial pigments. He served this position for two years and later he witnessed racism in Paris. He worked on the blood coagulation chemistry and published countless scientific research papers. These research papers were commonly related to the biopolymer nucleic acids, such as deoxyribonucleic acid DNA. He started his lifelong career at Columbia University and stayed here in his remaining life and awarded American citizenship in He became an assistant professor of biochemistry in He became a professor in and from to , Erwin Chargaff served as a chairman of the Department of Chemistry and retired as a professor emeritus of biochemistry.
When Erwin was working in Columbia University, he used the chromatographic techniques to study the nucleic acid such as DNA. In between to , he conducted research and turned their main focus on blood coagulation. In , when Chargaff was researching on blood coagulation then he heard about the research of Oswald Avery and his associates to discover new genes that were composed of DNA. Oswald and his colleagues conducted this research at the Rockefeller institute, New York.
Oswald Avery and his research associates concluded that the genes are made up of double-helix DNA. In , he traveled to the U. After two years, he left as he did not like his surroundings, and returned to Europe. Chargaff stayed in Europe for the first half of the s, working at the University of Berlin until He worked in the department of bacteriology and public health there as a senior chemistry assistant.
However, when the Nazis came to power in , his Jewish background meant that he was required to resign his post. He moved to Paris and spent a year in the city at the Pasteur Institute, working as a research assistant. Despite his earlier bad experiences at Yale, Chargaff decided to emigrate to the U. It was here that he would spend most of his working life. He was named an associate professor in , though WWII delayed his advancement to full professorial status until In , he retired as professor emeritus, then moving to Roosevelt Hospital until , when he retired completely from research.
He made considerable use of chromatography in this work. He was able to do this with the newly developed paper chromatography and ultraviolet spectrophotometer. Chargaff met Francis Crick and James D. Watson at Cambridge in , and, despite not getting on well with them personally, explained his findings to them. The second of Chargaff's rules is that the composition of DNA varies from one species to another, in particular in the relative amounts of A, G, T, and C bases.
Such evidence of molecular diversity, which had been presumed absent from DNA, made DNA a more credible candidate for the genetic material than protein.
Besides making these important steps toward the structure of DNA, Chargaff's lab also conducted research on the metabolism of amino acids and inositol , blood coagulation , lipids and lipoproteins , and the biosynthesis of phosphotransferases. Beginning in the s, Chargaff became increasingly outspoken about the failings of the field of molecular biology , claiming that molecular biology was "running riot and doing things that can never be justified.
The Prize can only be split three ways. Along with Chargaff, 23 other scientists contributed significantly to the double helix elucidation and were not rewarded with the Nobel for their work towards the double helix.
Chargaff wrote papers and 15 books on diverse topics during his retirement years. Category : Austrian biochemists. Read what you need to know about our industry portal bionity. My watch list my. My watch list My saved searches My saved topics My newsletter Register free of charge.
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