To help avoid interactions, your doctor should manage all of your medications carefully. Taking certain drugs with amitriptyline may cause serious side effects. You should not take these drugs and amitriptyline at the same time. Examples of these drugs include:.
Using an MAOI with amitriptyline can lead to seizures or even death. Do not take an MAOI within two weeks of stopping amitriptyline, unless told to do so by your doctor.
Also, do not start taking amitriptyline if you stopped taking a MAOI in the last two weeks, unless told to do so by your doctor. Taking amitriptyline with certain drugs raises your risk of negative effects. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:.
Typical starting dosage: 10 mg three times a day with 20 mg at bedtime, for a total of 50 mg per day. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly.
As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.
However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you. You might experience an initial worsening of your depression, thoughts of suicide, and behavioral changes when you first start taking amitriptyline. This risk may last until the drug starts working for you.
Stopping it suddenly may cause side effects such as nausea, headache, and tiredness. Do not stop taking this drug without talking with your doctor.
They will tell you how to slowly lower your dosage over time. Taking it again could be fatal cause death. The use of drinks that contain alcohol while taking amitriptyline raises your risk of serious side effects, including extreme drowsiness. For people with heart disorders: Taking this drug could cause heart problems, such as irregular heart rhythm, heart attack , and stroke. Your doctor should do this because a major depressive episode is usually the first symptom noticed in people with bipolar disorder.
This drug should not be used in people with bipolar disorder. For people with a history of seizures: Taking this drug raises your risk of seizures. If you have a seizure while taking this drug, stop taking it and call your doctor right away. For people with a history of glaucoma or increased eye pressure: Taking this drug could increase the pressure in your eyes.
For people who have schizophrenia: This drug can worsen certain symptoms of schizophrenia. If you have this condition, let your doctor know before starting this drug. For people who have urinary retention difficulty emptying your bladder completely : Taking this drug can worsen urinary retention.
For pregnant women: Amitriptyline is a category C pregnancy drug. That means two things:. Donna Hill Howes, RN. Research on duloxetine has found it to be about as effective as NSAIDs for improving pain and functi How long does it take for antidepressants to start working? Michael D. Banov, MD. In research studies that carefully measure when positive results from antidepressant therapy are see What conditions do antidepressants treat? Amitriptyline comes as a tablet to take by mouth.
It is usually taken one to four times a day. Take amitriptyline at around the same time s every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take amitriptyline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of amitriptyline and gradually increase your dose. It may take a few weeks or longer before you feel the full benefit of amitriptyline. Continue to take amitriptyline even if you feel well. Do not stop taking amitriptyline without talking to your doctor. If you suddenly stop taking amitriptyline, you may experience withdrawal symptoms such as nausea, headache, and lack of energy.
Your doctor will probably decrease your dose gradually. Amitriptyline is also used to treat eating disorders, post-herpetic neuralgia the burning, stabbing pains, or aches that may last for months or years after a shingles infection , and to prevent migraine headaches.
Talk to your doctor about the possible risks of using this medication for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Amitriptyline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at
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